Seifter E, Rettura G, Barbul A, Levenson S M
Surgery. 1978 Aug;84(2):224-30.
The influence of arginine supplements on growth and healing of skin incisional wounds was studied in rats fed either a chemically defined diet lacking arginine or a laboratory chow containing 1.8% arginine. Rats fed the arginine-free diet grew more poorly than did arginine-supplemented rats (1.8 vs. 7.0 gm/day) in the preoperative period. After operation arginine-deficient animals grew very poorly (1 gm/day), while arginine-supplemented rats gained 4.3 gm/day. Arginine-deficient animals showed impaired wound healing, as judged by the breaking strengths of their incisions 10 days after wounding (228 vs. 293 gm for the arginine-supplemented rats). Arginine-deficient rats also showed decreased collagen deposition in a specific wound site, as indicated by the decreased content in hydroxyproline in sponge granulomas (2.5 vs. 4.2 mg/100 mg. of sponge for the arginine-supplemented rats). In rats fed commercial chow, 1% arginine decreased the postoperative weight loss associated with injury (0.7 vs. 5.2 gm) in one experiment and improved wound strength in two experiments (312 vs. 188 gm in one experiment and 309 vs. 246 gm in another). Arginine also increased hydroxyproline deposition in a specific wound area (5.5 vs. 4.1 mg in one experiment and 3.1 vs. 1.9 mg. in another). It is concluded that arginine has two roles in wounded animals. It is essential for the synthesis of the increased amounts of reparative collagen required for wound healing, and it decreases some of the negative aspects of the metabolic responses to injury. These are thought to be associated with an arginine-induced growth hormone release.
在喂食缺乏精氨酸的化学限定饮食或含有1.8%精氨酸的实验室常规饲料的大鼠中，研究了精氨酸补充剂对皮肤切口伤口生长和愈合的影响。术前，喂食无精氨酸饮食的大鼠生长情况比补充精氨酸的大鼠差（分别为1.8克/天和7.0克/天）。术后，缺乏精氨酸的动物生长非常缓慢（1克/天），而补充精氨酸的大鼠体重每天增加4.3克。通过受伤10天后切口的抗张强度判断，缺乏精氨酸的动物伤口愈合受损（补充精氨酸的大鼠切口抗张强度为293克，而缺乏精氨酸的大鼠为228克）。缺乏精氨酸的大鼠在特定伤口部位的胶原蛋白沉积也减少，海绵肉芽肿中羟脯氨酸含量降低表明了这一点（补充精氨酸的大鼠海绵中羟脯氨酸含量为4.2毫克/100毫克海绵，而缺乏精氨酸的大鼠为2.5毫克/100毫克海绵）。在喂食商业常规饲料的大鼠中，1%的精氨酸在一项实验中减少了与损伤相关的术后体重减轻（分别为0.7克和5.2克），并在两项实验中提高了伤口强度（一项实验中分别为312克和188克，另一项实验中分别为309克和246克）。精氨酸还增加了特定伤口区域的羟脯氨酸沉积（一项实验中分别为5.5毫克和4.1毫克，另一项实验中分别为3.1毫克和1.9毫克）。得出的结论是，精氨酸在受伤动物中有两个作用。它对于伤口愈合所需的大量修复性胶原蛋白的合成至关重要，并且它减少了对损伤的代谢反应的一些负面影响。这些作用被认为与精氨酸诱导的生长激素释放有关。
