Vahouny G V, Connor W E, Subramaniam S, Lin D S, Gallo L L
Am J Clin Nutr. 1983 May;37(5):805-9. doi: 10.1093/ajcn/37.5.805.
Studies have been conducted on the lymphatic absorption of sitosterol (24 alpha-ethyl cholesterol), stigmasterol (delta 22, 24 alpha-ethyl cholesterol), and fucosterol (24-ethylidine cholesterol) when administered intragastrically to rats. In addition, the effect of each sterol on absorption of endogenous cholesterol has been assessed by including tracer cholesterol in the administered test emulsion. Analysis of 24-h lymph collections by GLC-mass spectrometry demonstrated that all three sterols were poorly absorbed to the extent of only 3 to 4% of the administered dose of 50 mg. In contrast, cholesterol absorption under similar conditions was about 42% of the administered dose. Administration of either sitosterol or stigmasterol resulted in an equally effective inhibition of cholesterol absorption (54%). Under identical conditions fucosterol had no effect on absorption of luminal cholesterol. The data suggest that the mechanism(s) for intestinal discrimination of sterols for absorption may be independent of the mechanism for interference with efficient cholesterol uptake by the intestine.
已经对大鼠经胃内给予谷甾醇（24α-乙基胆固醇）、豆甾醇（δ22, 24α-乙基胆固醇）和岩藻甾醇（24-亚乙基胆固醇）后的淋巴吸收情况进行了研究。此外，通过在给予的测试乳剂中加入示踪胆固醇，评估了每种甾醇对内源性胆固醇吸收的影响。通过气相色谱-质谱联用仪对24小时淋巴收集物进行分析表明，所有这三种甾醇的吸收都很差，仅为给予的50毫克剂量的3%至4%。相比之下，在类似条件下胆固醇的吸收约为给予剂量的42%。给予谷甾醇或豆甾醇均能同样有效地抑制胆固醇吸收（54%）。在相同条件下，岩藻甾醇对肠腔胆固醇的吸收没有影响。数据表明，肠道对甾醇吸收的辨别机制可能独立于肠道干扰有效摄取胆固醇的机制。
