Uchida K, Mizuno H, Hirota K, Takeda K, Takeuchi N, Ishikawa Y
Jpn J Pharmacol. 1983 Feb;33(1):103-12. doi: 10.1254/jjp.33.103.
Effects of spinasterol and sitosterol on plasma and liver cholesterol levels and biliary and fecal sterol and bile acid excretions were examined with male mice. Both phytosterols were added to the diet at a 1% concentration and fed to mice for 15 days. Spinasterol increased the fecal cholesterol excretion and decreased the plasma and liver cholesterol levels, the bile acid pool size and the fecal bile acid excretion, especially those derived from chenodeoxycholic acid. Fecal coprostanol excretion remained unchanged. These changes were similar to those produced by sitosterol. These data led to the conclusions 1) that spinasterol, as well as sitosterol, inhibits cholesterol absorption, resulting in decreases of the plasma and liver cholesterol levels and 2) that when cholesterol absorption is inhibited, the synthesis of bile acids, especially that of chenodeoxycholic acid, decreases, suggesting that the dietary cholesterol is preferentially metabolized to chenodeoxycholic acid in mice.
用雄性小鼠研究了菠菜甾醇和谷甾醇对血浆和肝脏胆固醇水平以及胆汁和粪便中甾醇及胆汁酸排泄的影响。两种植物甾醇均以1%的浓度添加到饮食中，并喂给小鼠15天。菠菜甾醇增加了粪便中胆固醇的排泄，降低了血浆和肝脏中的胆固醇水平、胆汁酸池大小以及粪便中胆汁酸的排泄，尤其是鹅去氧胆酸衍生的胆汁酸排泄。粪便中粪甾烷醇的排泄保持不变。这些变化与谷甾醇产生的变化相似。这些数据得出以下结论：1）菠菜甾醇以及谷甾醇均抑制胆固醇吸收，导致血浆和肝脏胆固醇水平降低；2）当胆固醇吸收受到抑制时，胆汁酸的合成，尤其是鹅去氧胆酸的合成减少，这表明在小鼠中，膳食胆固醇优先代谢为鹅去氧胆酸。
