Triplett D A, Brandt J T, Kaczor D, Schaeffer J
Am J Clin Pathol. 1983 Jun;79(6):678-82. doi: 10.1093/ajcp/79.6.678.
The introduction of the activated partial thromboplastin time (APTT) as a screening test has resulted in increased recognition of circulating anticoagulants. The most frequently encountered inhibitor is the lupus-type anticoagulant. However, criteria for differentiation of this inhibitor are not well-established. We evaluated the ability of two procedures, tissue thromboplastin inhibition (TTI) and a new platelet neutralization procedure (PNP), to differentiate between various types of coagulation inhibitors. The TTI, widely used for the diagnosis of lupus anticoagulants, proved to be nonspecific. The PNP specifically separated lupus-type inhibitors from Factor VIII, X, and V inhibitors. The PNP may be a useful test for the diagnosis of lupus anticoagulants.
活化部分凝血活酶时间（APTT）作为一种筛查试验的引入，使得循环抗凝物质的检出率有所提高。最常见的抑制剂是狼疮样抗凝物质。然而，这种抑制剂的鉴别标准尚未完全确立。我们评估了两种方法，即组织凝血活酶抑制试验（TTI）和一种新的血小板中和试验（PNP）区分各种凝血抑制剂的能力。广泛用于诊断狼疮抗凝物质的TTI被证明是非特异性的。PNP能将狼疮样抑制剂与因子VIII、X和V抑制剂特异性区分开来。PNP可能是诊断狼疮抗凝物质的一种有用试验。
