Dement J M, Harris R L, Symons M J, Shy C M
Am J Ind Med. 1983;4(3):421-33. doi: 10.1002/ajim.4700040304.
A retrospective cohort mortality study was conducted among a cohort of 1,261 white males employed one or more months in chrysotile asbestos textile operations and followed between 1940 and 1975. Statistically significant excess mortality was observed for all causes combined (standardized mortality ratio [SMR] = 150), lung cancer (SMR = 135), diseases of the circulatory system (SMR = 125), nonmalignant respiratory diseases (SMR = 294), and accidents (SMR = 134). Using estimated fiber exposure levels in conjunction with detailed worker job histories, exposure-response relationships were investigated. Strong exposure-response relationships for lung cancer and asbestos related non-malignant respiratory diseases were observed. Compared with data for chrysotile miners and millers, chrysotile textile workers were found to experience significantly greater lung cancer mortality at lower lifetime cumulative exposure levels. Factors such as differences in airborne fiber characteristics may partially account for the large differences in exposure response between textile workers and miners and millers.
对1261名在温石棉纺织作业中工作一个月或更长时间、并在1940年至1975年期间接受随访的白人男性队列进行了一项回顾性队列死亡率研究。观察到所有原因合并的统计学显著超额死亡率（标准化死亡率比[SMR]=150）、肺癌（SMR=135）、循环系统疾病（SMR=125）、非恶性呼吸系统疾病（SMR=294）和事故（SMR=134）。结合估计的纤维暴露水平和详细的工人工作史，研究了暴露-反应关系。观察到肺癌和石棉相关非恶性呼吸系统疾病的强暴露-反应关系。与温石棉矿工和磨工的数据相比，发现温石棉纺织工人在较低的终身累积暴露水平下经历的肺癌死亡率显著更高。空气传播纤维特性差异等因素可能部分解释了纺织工人与矿工和磨工之间暴露反应的巨大差异。
