Turner L J
Am J Surg. 1983 May;145(5):582-4. doi: 10.1016/0002-9610(83)90096-x.
Chronic pancreatitis may occasionally be due to chronic incomplete obstruction of the pancreatic duct. Pancreas divisum is associated with a high incidence of recurrent pancreatitis or pancreatic pain, which may be due to relative stenosis of the accessory papilla through which most of the pancreatic secretions drain. Stenosis of the pancreatic duct at the site of fusion of he ventral and dorsal ducts has been demonstrated in 3 percent of autopsy subjects and in patients studied with ERCP. Two patients with idiopathic chronic pancreatitis presented with dilatation of the pancreatic duct which extended distally from the site of fusion of the embryonic ducts. We postulate that congenital stenosis of the main pancreatic duct may predispose to chronic pancreatitis in the absence of other obvious etiologic factors.
慢性胰腺炎偶尔可能是由于胰管慢性不完全梗阻所致。胰腺分裂症与复发性胰腺炎或胰腺疼痛的高发病率相关,这可能是由于大多数胰液通过其引流的副乳头相对狭窄所致。在3%的尸检对象以及接受内镜逆行胰胆管造影(ERCP)检查的患者中,已证实胰管在腹侧和背侧胰管融合处存在狭窄。两名特发性慢性胰腺炎患者表现出胰管扩张,该扩张从胚胎胰管融合部位向远端延伸。我们推测,在没有其他明显病因的情况下,主胰管先天性狭窄可能易引发慢性胰腺炎。