多发性肌炎中针对肌红蛋白的细胞介导免疫。
Cell-mediated immunity to myoglobin in polymyositis.
作者信息
Herrera-Esparza R, Magaña L, Moreno J, Fraga A, Lavalle C
出版信息
Ann Rheum Dis. 1983 Apr;42(2):182-6. doi: 10.1136/ard.42.2.182.
Using the leucocyte migration inhibition (LIF) test we looked for evidence of cell-mediated hypersensitivity against myoglobin in 8 patients with polymyositis (PM) or dermatomyositis (DM). The migration index for PM-DM patients was 47.5 +/- 17%, while in the controls the index was 86 +/- 12% (p less than 0.001). The presence of serum antibodies against myoglobin was also investigated by passive haemagglutination (PH) and counterimmunoelectrophoresis (CIE). By PH the reciprocal titre of antimyoglobin antibodies was 150 +/- 28 in PM-DM compared with 16.2 +/- 15.9 and 8.7 +/- 7.7 in control patients with diseases (p less than 0.01) and negative in normal persons. CIE showed antimyoglobin antibodies in 3 PM-DM patients and in none of controls. Cell-mediated immunity against myoglobin may be implicated in the pathogenesis of PM. The pathological significance of antimyoglobin antibodies remains to be determined.
我们运用白细胞游走抑制（LIF）试验，探寻8例多发性肌炎（PM）或皮肌炎（DM）患者中针对肌红蛋白的细胞介导超敏反应的证据。PM - DM患者的游走指数为47.5±17%，而对照组的指数为86±12%（p＜0.001）。还通过被动血凝反应（PH）和对流免疫电泳（CIE）研究了抗肌红蛋白血清抗体的存在情况。通过PH检测，PM - DM患者抗肌红蛋白抗体的倒数滴度为150±28，而疾病对照组患者为16.2±15.9和8.7±7.7（p＜0.01），正常人呈阴性。CIE显示3例PM - DM患者存在抗肌红蛋白抗体，而对照组均无。针对肌红蛋白的细胞介导免疫可能与PM的发病机制有关。抗肌红蛋白抗体的病理意义尚待确定。
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