多发性肌炎中针对人肌红蛋白的循环自身抗体。
Circulating autoantibody against human myoglobin in polymyositis.
作者信息
Nishikai M, Homma M
出版信息
JAMA. 1977 Apr 25;237(17):1842-4.
PMID:576689
Abstract
A passive hemagglutination method for circulating autoantibody to purified human skeletal muscle myoglobin has been developed. This antibody was detected in the sera of 22 of 31 patients with polymyositis. The incidence and the antibody titers were significantly higher than in other myopathies such as myasthenia gravis (P less than .02), Duchenne-type muscular dystrophy (P less than .001), and other conditions (P less than .001). This new antibody test is useful in diagnosing polymyositis.
摘要
已开发出一种用于检测循环抗纯化人骨骼肌肌红蛋白自身抗体的被动血凝方法。在31例多发性肌炎患者中，有22例患者的血清检测到了这种抗体。其发生率和抗体滴度显著高于其他肌病，如重症肌无力（P<0.02）、杜兴型肌营养不良症（P<0.001）及其他病症（P<0.001）。这项新的抗体检测方法对多发性肌炎的诊断很有用。
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