Filser J G, Bolt H M
Arch Toxicol. 1983 Feb;52(2):123-33. doi: 10.1007/BF00354772.
A pharmacokinetic description of production, distribution and metabolism of endogenous volatile compounds is presented. This description uses the "gas uptake model" of a closed recirculated atmosphere in which experimental animals are exposed. As an example, the production rates of acetone, under different conditions of stimulation by xenobiotics, are calculated from published experimental data. The theoretical descriptions may serve as a basis for treating the problem of hydrocarbon exhalation in toxicological experiments with compounds eliciting lipid peroxidation.
本文对内源性挥发性化合物的产生、分布和代谢进行了药代动力学描述。该描述采用了封闭循环大气的“气体吸收模型”，实验动物在其中暴露。例如，根据已发表的实验数据计算了在不同外源性物质刺激条件下丙酮的产生速率。这些理论描述可为处理在毒理学实验中由引发脂质过氧化的化合物导致的碳氢化合物呼出问题提供依据。
