大鼠中卤代乙烯诱导的丙酮血症的特征

Characteristics of haloethylene-induced acetonemia in rats.

作者信息

Filser J G, Bolt H M

出版信息

Arch Toxicol. 1980 Jul;45(2):109-16. doi: 10.1007/BF01270908.

Abstract

A series of halogenated ethylenes (vinyl chloride, vinylidene fluoride, cis- and trans-1,2-dichloroethylene, perchloroethylene) induces increased acetone exhalation in rats. Exposures of differently pre-treated rats to vinylidene fluoride suggest that a metabolite of the haloethylene must be envolved in eliciting this formation of acetone. This conclusion is based on (a)dependence of acetone exhalation on the concentration of vinylidene fluoride, (b)effect of inducing agents, (c)effect of pyrazol, a metabolic inhibitor, (d)effect of cysteine, (e)effect of hypoxia and (f)the time course of acetone exhalation.

摘要

一系列卤代乙烯（氯乙烯、偏二氟乙烯、顺式和反式1,2 - 二氯乙烯、全氯乙烯）会使大鼠呼出的丙酮增加。对经过不同预处理的大鼠暴露于偏二氟乙烯的研究表明，卤代乙烯的一种代谢产物必定参与了引发丙酮的这种生成过程。这一结论基于以下几点：（a）丙酮呼出量对偏二氟乙烯浓度的依赖性；（b）诱导剂的作用；（c）代谢抑制剂吡唑的作用；（d）半胱氨酸的作用；（e）缺氧的作用；（f）丙酮呼出的时间进程。