Senges J, Mittmann U, Rizos I, Brachmann J, Beck L, Hammann H D, Braun W, Kübler W
Basic Res Cardiol. 1983 Jan-Feb;78(1):99-111. doi: 10.1007/BF01923197.
The effect of short bouts (1 min) of electrically induced ventricular tachycardias (VT) of increasing rates (160-240/min) was studied in 8 anesthetized dogs before and after graded constrictions of the left anterior descending (LAD) and the circumflex (CCA) coronary arteries. In the absence of coronary stenosis, paroxysmal VT caused a significant decrease in tension-time index (TTI), coronary blood flow (CBF) and coronary vascular resistance (CVR). Single and combined coronary stenosis caused relatively small alterations of the VT-induced depression of the systemic hemodynamics but reversed the effect of paroxysmal VT on the CVR. In the presence of single 90% LAD stenosis, VT resulted in an increase in CVR-LAD and a decrease in F-LAD associated with a fall in CVR-CCA and a rise in F-CCA. Combination of 90% LAD plus 70% CCA stenosis abolished the compensatory fall of CVR-CCA resulting in a pronounced reduction of F-CCA during VT. The results support the concept that in the presence of severe coronary stenosis brief paroxysmal ventricular tachycardias do increase myocardial nutritional demand but rather decrease nutritional supply.
在8只麻醉犬中，研究了在左前降支（LAD）和回旋支（CCA）冠状动脉分级缩窄前后，短阵（1分钟）、频率递增（160 - 240次/分钟）的电诱导室性心动过速（VT）的影响。在无冠状动脉狭窄时，阵发性VT导致张力 - 时间指数（TTI）、冠状动脉血流量（CBF）和冠状动脉血管阻力（CVR）显著降低。单一和联合冠状动脉狭窄引起VT诱导的全身血流动力学抑制的相对较小改变，但逆转了阵发性VT对CVR的影响。在存在单一90% LAD狭窄时，VT导致CVR - LAD增加和F - LAD降低，同时CVR - CCA降低和F - CCA升高。90% LAD加70% CCA狭窄的联合作用消除了CVR - CCA的代偿性降低，导致VT期间F - CCA明显减少。结果支持这样的概念，即在存在严重冠状动脉狭窄时，短暂的阵发性室性心动过速确实会增加心肌营养需求，但会减少营养供应。
