Edwards J A, Brimijoin S
Biochem Pharmacol. 1983 Apr 1;32(7):1183-9. doi: 10.1016/0006-2952(83)90269-1.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were examined in several tissues of normal and hypophysectomized male and female rats. Significant sex differences in the mean AChE activities of normal rats were observed in the superior cervical ganglion (three times more activity in males) and in serum (50% more activity in females). Sex differences in the BuChE activity of serum and liver were even larger (ten times more activity in females), but the activity of other tissues was similar in both sexes. Hypophysectomy had little effect on the mean activity of AChE but did alter BuChE activity in certain tissues. Most of the effects of hypophysectomy on mean BuChE activity were opposite in direction in the two sexes. For example, in males hypophysectomy caused increases in the BuChE activity of serum (300%) and liver (43%), while in females it caused decreases in both tissues (25 and 30% respectively). In rats of a given group, the AChE activity of each tissue appeared to be regulated independently of the activity in other tissues. By contrast, BuChE activity showed statistically significant correlations in more than half of the tissue-pairs examined in control rats of either sex. These correlations can be considered to reflect a tendency toward body-wide regulation. In female rats, the cross-tissue correlations were largely eliminated by hypophysectomy. This finding indicates that the regulation of BuChE may be strongly affected by hormones under the control of the pituitary gland. However, in male rats, only the correlations involving atria were altered by hypophysectomy. Therefore, the effects of hormones on BuChE are probably both sex and tissue dependent.
在正常和垂体切除的雄性及雌性大鼠的多个组织中检测了乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）的活性。在正常大鼠的颈上神经节中观察到AChE平均活性存在显著的性别差异（雄性活性高3倍），在血清中也存在性别差异（雌性活性高50%）。血清和肝脏中BuChE活性的性别差异更大（雌性活性高10倍），但其他组织的活性在两性中相似。垂体切除对AChE的平均活性影响较小，但确实改变了某些组织中的BuChE活性。垂体切除对平均BuChE活性的大多数影响在两性中的方向相反。例如，在雄性大鼠中，垂体切除导致血清（300%）和肝脏（43%）的BuChE活性增加，而在雌性大鼠中，垂体切除导致这两个组织中的活性均降低（分别降低25%和30%）。在给定组的大鼠中，每个组织的AChE活性似乎独立于其他组织的活性进行调节。相比之下，在任一性别的对照大鼠中，超过一半的检测组织对中，BuChE活性显示出统计学上显著的相关性。这些相关性可被认为反映了全身调节的趋势。在雌性大鼠中，垂体切除在很大程度上消除了跨组织的相关性。这一发现表明，BuChE的调节可能受到垂体控制下的激素的强烈影响。然而，在雄性大鼠中，垂体切除仅改变了涉及心房的相关性。因此，激素对BuChE的影响可能既取决于性别也取决于组织。
