Pajak S, Subczyński W, Panz T, Lukiewicz S
Folia Histochem Cytochem (Krakow). 1980;18(1):33-9.
It has been reported in recent years that the level of radiosensitivity of neoplastic cells in vivo and of sphaeroids in vitro can be modified by controlling their rate of oxygen consumption. Thus, an attempt was made to compare this rate in the case of the melanotic and amelanotic lines of Bomirski hamster melanoma in vitro, as it is known that these two lines distinctly differ in their reactivity to ionizing radiations. The measurements carried out by the use of a new ESR method revealed that pigmented and pigmentless cells consume oxygen at significantly different rates. This means that oxygen utilization may contribute to the overall level of radioresistance of melanoma cells.
近年来有报道称，通过控制肿瘤细胞在体内的耗氧率以及体外球体的耗氧率，可以改变它们的放射敏感性。因此，有人试图比较体外培养的博米尔斯基仓鼠黑色素瘤的黑色素瘤细胞系和无黑色素瘤细胞系的耗氧率，因为众所周知，这两个细胞系对电离辐射的反应明显不同。使用一种新的电子自旋共振（ESR）方法进行的测量表明，有色素和无色素的细胞消耗氧气的速率显著不同。这意味着氧的利用可能有助于黑色素瘤细胞的总体放射抗性水平。
