McMurtry J P, Wexler B C
Endocrinology. 1983 Jan;112(1):166-71. doi: 10.1210/endo-112-1-166.
Hypertension-prone, male, spontaneously hypertensive rats (SHR; n = 60) and normotensive, male, Sprague-Dawley rats (S-D; n = 60) were exposed to the relatively innocuous stimulus of heat and ether when they were 40 days of age, just before the usual onset of high blood pressure in SHR. The animals were decapitated 0, 2, 5, 15, and 60 min postexposure to heat and ether. Blood levels of corticosterone, aldosterone, PRL, GH were measured concomitant with pituitary content of GH and PRL and adrenal content of ascorbic acid and cholesterol. The foregoing constituents were used as an index of pituitary-adrenal responsiveness. Changes in circulating corticosterone, PRL, GH, and especially aldosterone indicated that before the onset of their high blood pressure, SHR are much more responsive to noxious stimuli than normotensive S-D. The pattern of change in the pituitary content of GH and PRL, adrenal ascorbate, and cholesterol were also indicative of SHR hypersensitivity. These findings suggest that adrenal steroidogenesis and the stress response pattern in SHR vs. normotensive rats may be unique.
高血压易感雄性自发性高血压大鼠（SHR；n = 60）和血压正常的雄性斯普拉格-道利大鼠（S-D；n = 60）在40日龄时，即在SHR通常开始出现高血压之前，接受相对无害的热和乙醚刺激。在暴露于热和乙醚后0、2、5、15和60分钟将动物断头。测量皮质酮、醛固酮、催乳素、生长激素的血药浓度，同时测量垂体中生长激素和催乳素的含量以及肾上腺中抗坏血酸和胆固醇的含量。上述成分用作垂体-肾上腺反应性的指标。循环中的皮质酮、催乳素、生长激素，尤其是醛固酮的变化表明，在高血压发作之前，SHR对有害刺激的反应比血压正常的S-D大鼠敏感得多。垂体中生长激素和催乳素的含量、肾上腺抗坏血酸盐和胆固醇的变化模式也表明SHR具有高敏感性。这些发现表明，SHR与血压正常的大鼠相比，肾上腺类固醇生成和应激反应模式可能是独特的。
