McMurtry J P, Wexler B C
Endocrinology. 1981 May;108(5):1730-6. doi: 10.1210/endo-108-5-1730.
The responses to immobilization, ether, and heat of spontaneously hypertensive rats (SHR) and normotensive Sprague-Dawley rats (S-D) were compared. Hyperglycemia reached a maximum within 5 min of exposure and was most intense in SHR. There were no differences in the pituitary content of GH or PRL between the SHR and S-D. Circulating GH levels were especially depleted in SHR 15 min post exposure, with rebound to high blood levels at 1 h. Circulating PRL levels were slightly higher in quiescent SHR vs. S-D but surged to much higher levels post exposure in SHR vs. S-D. Postexposure blood corticosterone and aldosterone levels rose to much higher levels in SHR vs. S-D. Although the blood glucose, GH, PRL, corticosterone, and aldosterone levels are similar in hypertensive SHR and normotensive S-D under quiescent conditions, SHR appear to be much more sensitive and respond more vigorously to heat, ether, and immobilization. It is suggested that abnormal activity of the hypothalamic-pituitary system may play a role in the pathogenesis of the genetically programmed hypertension of SHR.
比较了自发性高血压大鼠（SHR）和正常血压的斯普拉格-道利大鼠（S-D）对制动、乙醚和热刺激的反应。暴露后5分钟内血糖达到峰值，且在SHR中最为强烈。SHR和S-D之间垂体中生长激素（GH）或催乳素（PRL）的含量没有差异。暴露后15分钟，SHR中循环GH水平尤其降低，1小时时反弹至高水平。静息状态下，SHR中循环PRL水平略高于S-D，但暴露后SHR中PRL水平相比S-D飙升至更高水平。暴露后，SHR中血皮质酮和醛固酮水平相比S-D升至更高水平。尽管在静息条件下，高血压SHR和正常血压S-D的血糖、GH、PRL、皮质酮和醛固酮水平相似，但SHR似乎对热、乙醚和制动更为敏感且反应更强烈。提示下丘脑-垂体系统的异常活动可能在SHR遗传性高血压的发病机制中起作用。
