鹅去氧胆酸治疗期间影响胆结石溶解速率的因素。
Factors affecting gall-stone dissolution rate during chenic acid therapy.
作者信息
Maudgal D P, Kupfer R M, Northfield T C
出版信息
Gut. 1983 Jan;24(1):7-10. doi: 10.1136/gut.24.1.7.
Abstract
Gall-stone dissolution rate was measured in 52 patients with radiolucent gall stones in a functioning gall bladder receiving chenic acid 15 mg/kg/day. Percentage reduction in gall-stone area at six months was inversely related to initial gall-stone diameter (n = 52; r = -0.53; p less than 0.001), and to cholesterol saturation index of fasting gall-bladder bile during treatment (n = 28; r = -0.61; p less than 0.001). The duration of treatment required for complete dissolution was directly related to initial gall-stone diameter (r = 0.47; p less than 0.02). We conclude that the rate of gall-stone dissolution depends not only on gall-stone size but also on the degree of unsaturation of gall-bladder bile achieved during chenic acid treatment.
摘要
对52例胆囊功能正常、患有透X线胆结石的患者，给予鹅去氧胆酸15mg/kg/天，测量其胆结石溶解率。6个月时胆结石面积减少的百分比与初始胆结石直径呈负相关（n = 52；r = -0.53；p < 0.001），与治疗期间空腹胆囊胆汁的胆固醇饱和指数呈负相关（n = 28；r = -0.61；p < 0.001）。完全溶解所需的治疗时间与初始胆结石直径直接相关（r = 0.47；p < 0.02）。我们得出结论，胆结石溶解率不仅取决于胆结石大小，还取决于在鹅去氧胆酸治疗期间胆囊胆汁达到的不饱和程度。
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