Weir B, Gordon P
J Neurosurg. 1983 Feb;58(2):242-5. doi: 10.3171/jns.1983.58.2.0242.
Plasminogen, alpha2-antiplasmin, fibrinogen, fibrin degradation products (FDP's), and hemoglobin were measured in the supernatant fluid of 25 chronic subdural hematomas and five chronic subdural hygromas. The 30 patients underwent pre- and postoperative computerized tomography. The hematomas were characterized by low fibrinogen and high fibrin degradation product concentrations. The hemoglobin content varied directly with the alpha2-antiplasmin, and inversely with the plasminogen. Four patients underwent reoperation for recurrences. The initial fluid from these cases was characterized by relatively high plasminogen and low alpha2-antiplasmin. The hygromas had no hemoglobin, and low fibrinogen, high FDP's, low alpha2-antiplasmin, and variable plasminogen levels. It is possible that those cases having the greatest capacity to produce plasmin (high plasminogen and low alpha2-antiplasmin) can produce more FDP's which in turn causes more rebleeding and an increased risk of reaccumulation of chronic subdural hematomas.
对25例慢性硬膜下血肿和5例慢性硬膜下积液患者的上清液进行了纤溶酶原、α2-抗纤溶酶、纤维蛋白原、纤维蛋白降解产物（FDP）和血红蛋白的检测。这30例患者均接受了术前和术后的计算机断层扫描。血肿的特点是纤维蛋白原浓度低，纤维蛋白降解产物浓度高。血红蛋白含量与α2-抗纤溶酶呈正相关，与纤溶酶原呈负相关。4例患者因复发接受了再次手术。这些病例的初始液体的特点是纤溶酶原相对较高，α2-抗纤溶酶较低。积液中没有血红蛋白，纤维蛋白原含量低，FDP含量高，α2-抗纤溶酶含量低，纤溶酶原水平变化不定。那些产生纤溶酶能力最强（纤溶酶原高而α2-抗纤溶酶低）的病例可能会产生更多的FDP，进而导致更多的再出血以及慢性硬膜下血肿再积聚的风险增加。
