Hill R, Robbins A W, Messing R, Arora N S
Am Rev Respir Dis. 1983 Jan;127(1):129-31. doi: 10.1164/arrd.1983.127.1.129.
We present a case of severe breathing abnormality during sleep in a young man who had had poliomyelitis 20 yr before. His sleep disorder led to respiratory failure and cor pulmonale, which were greatly improved by oxygen therapy. A study of this case and those previously described supports the notion that brainstem damage during acute poliomyelitis is important in the later appearance of sleep-disordered breathing. In addition, such patients usually have mechanical abnormalities involving the thoracic cage and respiratory muscles. These ventilatory restrictions amplify the pathophysiologic effects of abnormal central nervous system control of breathing during sleep, and we suggest that their presence has a key role in the development of sleep apnea syndrome in these patients.
我们报告一例20年前患过小儿麻痹症的年轻男性在睡眠期间出现严重呼吸异常的病例。他的睡眠障碍导致呼吸衰竭和肺心病，通过氧疗得到了极大改善。对该病例及先前描述病例的研究支持这样一种观点，即急性小儿麻痹症期间的脑干损伤对睡眠呼吸障碍的后期出现具有重要意义。此外，这类患者通常存在涉及胸廓和呼吸肌的机械性异常。这些通气限制会放大睡眠期间中枢神经系统对呼吸异常控制的病理生理效应，我们认为它们的存在在这些患者睡眠呼吸暂停综合征的发生中起关键作用。
