Saint-Remy J R, Mitchell D N, Cole P J
Am Rev Respir Dis. 1983 Jan;127(1):23-7. doi: 10.1164/arrd.1983.127.1.23.
Sixty-three patients with clinically definite sarcoidosis confirmed histologically and/or by a positive Kveim test were studied according to the clinical and radiographic extent and known duration of their disease and symptoms. Immunoglobulin levels were not raised among patients with bilateral hilar lymphadenopathy (BHL) alone, but IgG and IgA were raised among patients with pulmonary sarcoidosis, most markedly among patients with long-standing active disease. Serum IgM was found elevated in extrathoracic sarcoidosis. West Indian males had the highest levels of IgG. The presence of circulating immune complexes reacting with conglutinin was strongly associated with a recent symptomatic onset of sarcoidosis; they were more prevalent in patients with BHL and erythema nodosum. In contrast, polyethylene glycol precipitable immunoglobulins were associated with long-standing active disease and with neurologic involvement.
对63例经组织学确诊和/或Kveim试验阳性的临床确诊结节病患者，根据其疾病的临床和影像学范围、已知病程及症状进行了研究。单纯双侧肺门淋巴结肿大（BHL）患者的免疫球蛋白水平未升高，但肺结节病患者的IgG和IgA升高，在长期活动性疾病患者中最为明显。血清IgM在胸外结节病中升高。西印度男性的IgG水平最高。与胶固素反应的循环免疫复合物的存在与结节病近期症状发作密切相关；它们在BHL和结节性红斑患者中更为普遍。相比之下，聚乙二醇可沉淀免疫球蛋白与长期活动性疾病和神经受累有关。
