Jones J V, Cumming R H, Asplin C M
Ann N Y Acad Sci. 1976;278:212-9. doi: 10.1111/j.1749-6632.1976.tb47032.x.
Twenty-two patients were investigated during acute attacks of erythema nodosum with a series of tests for circulating immune complexes. Nineteen had bilateral hilar lymphadenopathy and were considered to have sarcoidosis. Evidence of circulating immune complexes was found in 18, out of 22 patients (including 15 out of the 19 cases of sarcoidosis). The most frequent abnormality was the detection of elevated levels of C3 breakdown products (C3i), which were found in 14 out of 18 tests. The test results returned gradually to normal as symptoms subsided in 20-40 days, but 2 patients still showed abnormalities at 40 days despite the disappearance of symptoms. It is concluded that free immune complexes appear in the circulation during the early stages of acute sarcoidosis and gradually disappear as symptoms subside.
对22例结节性红斑急性发作期的患者进行了一系列循环免疫复合物检测。其中19例有双侧肺门淋巴结肿大，被认为患有结节病。22例患者中有18例（包括19例结节病患者中的15例）发现有循环免疫复合物的证据。最常见的异常是检测到C3裂解产物（C3i）水平升高，在18次检测中有14次出现这种情况。随着症状在20 - 40天内消退，检测结果逐渐恢复正常，但有2例患者在40天时尽管症状已消失，但仍显示异常。结论是，游离免疫复合物在急性结节病早期出现在循环中，并随着症状消退而逐渐消失。
