Wittman D H, Schassan H H
Arch Surg. 1983 Feb;118(2):205-13. doi: 10.1001/archsurg.1983.01390020055010.
Serial serum and peritoneal fluid samples were taken after intravenous injection of cefuroxime sodium, cefoxitin sodium, cefotaxime sodium, cefoperazone sodium, ceftazidime, moxalactam disodium, mezlocillin sodium, and piperacillin sodium. Time-concentration curves were obtained for both pharmacokinetic compartments. The geometric mean of peritoneal fluid concentrations from eight to ten patients was used to define the time-concentrations curve for each substance. Serum pharmacokinetic values were calculated using an open two-compartment model. The concentrations (Cps) were calculated from peritoneal fluid concentrations by quadratic interpolation. The time for which one fourth of the Cp (Cp1/4) is maintained within the peritoneal cavity varied according to the substance and can be used to estimate dosage intervals. The Cp1/4 was compared with the minimal inhibitory concentrations for 1,344 pathogens encountered in 415 intra-abdominal infections from 31 studies.
静脉注射头孢呋辛钠、头孢西丁钠、头孢噻肟钠、头孢哌酮钠、头孢他啶、拉氧头孢二钠、美洛西林钠和哌拉西林钠后，采集系列血清和腹腔液样本。获得了两个药代动力学房室的时间-浓度曲线。使用八至十名患者腹腔液浓度的几何平均值来确定每种物质的时间-浓度曲线。血清药代动力学值采用开放二房室模型计算。浓度（Cps）通过二次插值法从腹腔液浓度计算得出。腹腔内维持四分之一Cp（Cp1/4）的时间因物质而异，可用于估计给药间隔。将Cp1/4与31项研究中415例腹腔内感染中遇到的1344种病原体的最低抑菌浓度进行比较。
