Rao N A, Robin J, Hartmann D, Sweeney J A, Marak G E
Arch Ophthalmol. 1983 Jan;101(1):102-4. doi: 10.1001/archopht.1983.01040010104019.
Clinical observations have established that sympathetic ophthalmia (SO) develops after a penetrating wound but not subsequent to often more severe intraocular disturbances such as extensive photocoagulation. A feature of the penetrating wound that appears important in the pathogenesis of SO is the access it provides for intraocular antigens to reach regional lymph nodes. The intraocular compartment has no lymphatic drainage and appears to function like a number of alymphatic biologic sites. In an experimental model of SO, subconjunctival injection of retinal S antigen in one eye induced a bilateral sympathetic uveitis, whereas intraocular injection in one eye was ineffective in inducing sympathetic disease.
临床观察已证实，交感性眼炎（SO）在眼球穿通伤后发生，但在诸如广泛光凝等往往更为严重的眼内病变之后却不会发生。在SO发病机制中似乎很重要的一个眼球穿通伤特征是，它为眼内抗原到达局部淋巴结提供了途径。眼内间隙没有淋巴引流，其功能似乎类似于一些无淋巴的生物部位。在SO的实验模型中，在一只眼的结膜下注射视网膜S抗原可诱发双侧交感性葡萄膜炎，而在一只眼内注射则不能诱发交感性疾病。
