De Remigis P, Damiani A, Menduni P, Guagnano M T, Vianale L, D'Angelo M, Bonaduce A, Di Sciascio F, Liberatoscioli C, Sensi S
Boll Soc Ital Biol Sper. 1983 Jan 31;59(1):33-5.
Previous reports demonstrate a circadian rhythm of the free thyroid hormones in healthy subjects. In this study we evaluated circadian variation of FT3 and FT4 in hyperthyroid and hypothyroid states. We considered six hyperthyroid patients, six hypothyroid patients and six control subjects. Blood samples were taken two hours apart from a catherterized arm vein. Data were evaluated by Halberg's cosinor analysis. The results show that FT3 and FT4 exhibit a circadian rhythm in healthy subjects, not evident in hyperthyroid and hypothyroid patients.
先前的报告表明，健康受试者体内游离甲状腺激素存在昼夜节律。在本研究中，我们评估了甲状腺功能亢进和减退状态下FT3和FT4的昼夜变化。我们纳入了6例甲状腺功能亢进患者、6例甲状腺功能减退患者和6例对照受试者。从经导管插入的手臂静脉每隔两小时采集一次血样。数据采用哈尔伯格余弦分析进行评估。结果显示，FT3和FT4在健康受试者中呈现昼夜节律，而在甲状腺功能亢进和减退患者中不明显。
