Ajala M O, Ogunro P S, Fasanmade O A
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology. Osogbo. Nigeria.
Niger Postgrad Med J. 2013 Sep;20(3):188-92.
To evaluated the effect of thyroid dysfunction on liver function tests and if there is any correlation between them.
A total of 68 subjects (40 hyperthyroid and 28 hypothyroid) between the ages of 20-60 years old and 40 healthy euthyroid volunteers of the same age groups were studied. Plasma albumin, bilirubin (total and conjugated), thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH); activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT) were estimated in the plasma of the participants.
Plasma concentration of Total .bilirubin and liver enzyme activities increased significantly in both hyperthyroid and hypothyroid subjects. The positive correlations between thyroid hormones and liver enzymes in hyperthyroid subjects were negative in hypothyroid subjects and vice-visa.
It can be concluded that both hyperthyroidism and hypothyroidism altered liver function tests. It is thus recommended that liver function tests interpretation in thyroid dysfunction should be with caution.
评估甲状腺功能障碍对肝功能检查的影响以及两者之间是否存在相关性。
研究了68名年龄在20至60岁之间的受试者（40名甲状腺功能亢进者和28名甲状腺功能减退者）以及40名同年龄组的健康甲状腺功能正常志愿者。测定了参与者血浆中的白蛋白、胆红素（总胆红素和结合胆红素）、甲状腺素（T4）、三碘甲状腺原氨酸（T3）、促甲状腺激素（TSH）；天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）的活性。
甲状腺功能亢进和甲状腺功能减退受试者的血浆总胆红素浓度和肝酶活性均显著升高。甲状腺功能亢进受试者中甲状腺激素与肝酶之间的正相关在甲状腺功能减退受试者中为负相关，反之亦然。
可以得出结论，甲状腺功能亢进和甲状腺功能减退都会改变肝功能检查结果。因此建议在甲状腺功能障碍时解读肝功能检查结果应谨慎。
