Arnold J M, McDevitt D G
Br J Clin Pharmacol. 1983 Apr;15(4):423-9. doi: 10.1111/j.1365-2125.1983.tb01525.x.
1 Eight healthy subjects (six male, two female, aged 18-21 years) received graded intravenous bolus injections of isoprenaline sulphate. Heart rate and intra-arterial blood pressure were continuously monitored PRE- and POST-atropine (0.04 mg/kg). 2 PRE-atropine, an increase in heart rate of 25 beats/min was produced by 2.15 +/- 0.53 micrograms of isoprenaline and was associated with a fall in mean, systolic and diastolic pressures (18.9 +/- 2.8, 17.7 +/- 3.4 and 20.4 +/- 2.3 mm Hg respectively). 3 POST-atropine, the heart rate dose response curve was shifted to the right so that the dose of isoprenaline which increased heart rate 25 beats/min PRE-atropine, produced a significantly smaller heart rate rise of 20.3 +/- 1.7 beats/min (P less than 0.001). This was associated with a shift of the blood pressure dose-response curves to the left, and larger falls in mean, systolic and diastolic pressures (30.9 +/- 2.8, 31.8 +/- 3.3, 30.1 +/- 3.3 mm Hg respectively; P less than 0.01). 4 It is concluded that there is a significant contribution from a reflex withdrawal of cardiac vagal tone, to the tachycardia produced by a bolus of isoprenaline.
八名健康受试者（六名男性，两名女性，年龄18 - 21岁）接受了硫酸异丙肾上腺素的分级静脉推注。在注射阿托品（0.04mg/kg）前后持续监测心率和动脉内血压。
在注射阿托品前，2.15±0.53微克的异丙肾上腺素使心率增加25次/分钟，并伴有平均压、收缩压和舒张压下降（分别为18.9±2.8、17.7±3.4和20.4±2.3mmHg）。
注射阿托品后，心率剂量反应曲线右移，因此在注射阿托品前使心率增加25次/分钟的异丙肾上腺素剂量，注射后心率升高明显较小，为20.3±1.7次/分钟（P<0.001）。这与血压剂量反应曲线左移以及平均压、收缩压和舒张压下降幅度更大有关（分别为30.9±2.8、31.8±3.3、30.1±3.3mmHg；P<0.01）。
结论是，心脏迷走神经张力反射性撤离对异丙肾上腺素推注引起的心动过速有显著作用。
