Kozlov M M, Markin V S
Biofizika. 1983 Mar-Apr;28(2):242-7.
The stalker mechanism of membrane fusion was considered. Initiation and evolution of monolayer and bilayer bridges-stalks between the membranes were studied. From the expression of elastic energy of the stalk the value of spontaneous curvature of its membrane Ks at which the bridge may appear, was found. It was shown that in terms of the stalker mechanism formation of the stalk of the final radius or complete fusion were possible Ks values for realizing this or that variant were found. The energetic barrier of hydrophobic interaction and the barrier of elastic energy which the membranes had to overcome for stalker formation were found. The experimental data on the fusion of small and large liposomes were analysed.
考虑了膜融合的“茎形成”机制。研究了膜之间单层和双层桥(茎)的起始和演化。从茎的弹性能表达式中,找到了膜的自发曲率值Ks,在该值下桥可能出现。结果表明,就“茎形成”机制而言,最终半径的茎或完全融合的形成是可能的,找到了实现这种或那种变体的Ks值。发现了疏水相互作用的能量屏障以及膜形成茎时必须克服的弹性能量屏障。分析了关于小脂质体和大脂质体融合的实验数据。