Watson R T, Heilman K M
Brain. 1983 Jun;106 (Pt 2):391-403. doi: 10.1093/brain/106.2.391.
A 43-year-old woman suffered a spontaneous corpus callosum disconnection, resulting in apraxia and apraxic agraphia confined to the left hand. She initially had a functionally total callosal disconnection. With time, the splenium of the corpus callosum became functional, and a computerized tomographic scan performed five months after the onset showed infarction of only the body of the corpus callosum. Concomitant with this improvement in callosal function, the apraxia changed from ideational (loss of the concept of skilled movements) to classic ideomotor apraxia. A temporal analysis of this case provided support for Liepmann's (Liepmann, 1900; Liepmann and Maas, 1970) hypothesis that there is a centre for visuokinaesthetic (space-time) engrams in the left hemisphere of right-handed patients that controls skilled motor acts in either hand. This patient's recovery also allowed us a better understanding of the mechanisms underlying various types of apraxia.
一名43岁女性发生自发性胼胝体离断，导致仅累及左手的失用症和失用性失写症。她最初存在功能性完全胼胝体离断。随着时间推移，胼胝体压部恢复功能，发病五个月后进行的计算机断层扫描显示仅胼胝体体部梗死。随着胼胝体功能的这种改善，失用症从观念性（熟练动作概念丧失）转变为典型的观念运动性失用症。对该病例的时间分析为利普曼（Liepmann，1900年；Liepmann和Maas，1970年）的假说提供了支持，即右利手患者左半球存在一个视觉运动觉（时空）记忆痕迹中心，该中心控制任何一只手的熟练运动行为。该患者的康复也使我们能更好地理解各种类型失用症的潜在机制。
