Lox C D, Heine M W
Contraception. 1983 Apr;27(4):401-7. doi: 10.1016/s0010-7824(83)80019-5.
Female rats were given either ethinyl estradiol or norethindrone in conjunction with water or 5% ethanol. Hematological parameters measured included the prothrombin time (PT), partial thromboplastin time (APTT), fibrinogen (FIB), factors II, V, VII, VIII, X, and XII activity; plus the platelet count (PLT) and hematocrit (HCT). The data indicates that norethindrone together with water produces the greatest number of changes in clotting activity.
给雌性大鼠服用炔雌醇或炔诺酮,并同时给予水或5%乙醇。所测量的血液学参数包括凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、因子II、V、VII、VIII、X和XII活性;以及血小板计数(PLT)和血细胞比容(HCT)。数据表明,炔诺酮与水一起服用时,凝血活性的变化数量最多。