Lox C D
J Environ Pathol Toxicol Oncol. 1985 Sep-Oct;6(1):51-5.
Female rats were exposed to a drinking solution containing either 650 or 1950 parts per million (ppm) of the organophosphate insecticide malathion for 14 days. Plasma samples were assayed for prothrombin time (PT), partial thromboplastin time (APTT), hematocrit (HCT), platelet count (PLT) and clot activation time for fibrinogen and coagulation factors, II, V, VII, VIII, X, and XII. Significant changes following 650 ppm malathion were noted for the fibrinogen, factors VII and XII. Drinking 1950 ppm malathion causes significant differences in factors II, VII, X and XII. The data strongly suggest that in the rat, malathion ingestion has a potent effect on blood coagulation.
将雌性大鼠暴露于含有百万分之650或1950（ppm）有机磷酸酯杀虫剂马拉硫磷的饮用溶液中14天。检测血浆样本的凝血酶原时间（PT）、部分凝血活酶时间（APTT）、血细胞比容（HCT）、血小板计数（PLT）以及纤维蛋白原和凝血因子II、V、VII、VIII、X和XII的凝血激活时间。在摄入百万分之650的马拉硫磷后，纤维蛋白原、因子VII和XII出现了显著变化。饮用百万分之1950的马拉硫磷会导致因子II、VII、X和XII出现显著差异。数据有力地表明，在大鼠中，摄入马拉硫磷对血液凝固有显著影响。
