短期接触二嗪农对大鼠血液凝固活性的影响。

The effects of short term diazinon exposure on blood clotting activity in the rat.

作者信息

Lox C D

出版信息

J Environ Pathol Toxicol Oncol. 1987 Jan-Feb;7(3):67-71.

Abstract

Female rats were exposed to a drinking solution containing 157 parts per million (ppm) of the organophosphate insecticide diazinon for 14 days. Plasma samples were assayed for prothrombin time (PT), partial thromboplastin time (APTT), hematocrit (HCT), platelet count (PLT) and clotting times for coagulation factors I (Fibrinogen), II, V, VII, VIII, X and XII. Significant change following ingestion of diazinon were noted for the PT, APTT, Fibrinogen, factors II, VII, VIII, X, XII and hematocrit. The data suggest that in the rat, diazinon ingestion has a direct effect on the clotting activity of various blood coagulation parameters.

摘要

将雌性大鼠暴露于含有百万分之一百五十七（ppm）有机磷杀虫剂二嗪农的饮用溶液中14天。检测血浆样本的凝血酶原时间（PT）、部分凝血活酶时间（APTT）、血细胞比容（HCT）、血小板计数（PLT）以及凝血因子I（纤维蛋白原）、II、V、VII、VIII、X和XII的凝血时间。摄入二嗪农后，PT、APTT、纤维蛋白原、因子II、VII、VIII、X、XII和血细胞比容出现显著变化。数据表明，在大鼠中，摄入二嗪农对各种血液凝固参数的凝血活性有直接影响。