Wilson T A, Melton T, Clarke W L
Diabetes Care. 1983 Mar-Apr;6(2):160-5. doi: 10.2337/diacare.6.2.160.
In an attempt to differentiate the effect of fenfluramine hydrochloride from that of caloric restriction on carbohydrate tolerance in patients with lipodystrophy, parameters of carbohydrate homeostasis were studied in patients with lipodystrophy during periods of fenfluramine treatment and during periods of caloric restriction. Although, carbohydrate tolerance appeared to improve initially in one patient when treated with fenfluramine, this improvement did not permit. No beneficial influence of fenfluramine on carbohydrate tolerance could be identified in the other patients studied. By contrast, all patients demonstrated an improvement in carbohydrate tolerance in response to caloric restriction. These data suggest that caloric restriction improved carbohydrate tolerance in patients with lipodystrophy whereas fenfluramine, in the absence of caloric restriction, has no long-term beneficial effect.
为了区分盐酸芬氟拉明与热量限制对脂肪营养不良患者碳水化合物耐受性的影响，我们对脂肪营养不良患者在服用芬氟拉明期间和热量限制期间的碳水化合物稳态参数进行了研究。尽管有一名患者在接受芬氟拉明治疗时碳水化合物耐受性最初似乎有所改善，但这种改善并不持久。在其他研究的患者中未发现芬氟拉明对碳水化合物耐受性有有益影响。相比之下，所有患者在热量限制后碳水化合物耐受性均有所改善。这些数据表明，热量限制可改善脂肪营养不良患者的碳水化合物耐受性，而在没有热量限制的情况下，芬氟拉明没有长期有益效果。
