Theodore W H, Schulman E A, Porter R J
Epilepsia. 1983 Jun;24(3):336-43. doi: 10.1111/j.1528-1157.1983.tb04897.x.
Seventy-four patients with intractable seizures were followed up 6 to 57 months (mean 25 months) after intensive monitoring. At discharge from the hospital, 59% of the patients had at least a 50% reduction in seizure frequency and 63% had decreased antiepileptic drug toxicity. The findings at follow-up compared with those at admission showed reduced seizure frequency in 55% of the patients, diminished medication toxicity in 54%, and improved social adjustment in 38%. A change in the seizure diagnosis was the best predictor of a favorable outcome. Patients with impaired mental status were not less likely to improve. The relationship between seizure type and outcome was not significant, although patients with complex partial seizures tended to be less likely to improve. Intensive monitoring can lead to significant long-lasting improvement of patients with severe epilepsy.
74例难治性癫痫患者在强化监测后随访6至57个月（平均25个月）。出院时，59%的患者癫痫发作频率至少降低了50%，63%的患者抗癫痫药物毒性降低。随访结果与入院时相比，55%的患者癫痫发作频率降低，54%的患者药物毒性减轻，38%的患者社会适应能力改善。癫痫诊断的改变是预后良好的最佳预测指标。精神状态受损的患者改善的可能性并不小。癫痫发作类型与预后之间的关系不显著，尽管复杂部分性发作的患者改善的可能性往往较小。强化监测可使重度癫痫患者获得显著的长期改善。
