EEG profile of the anticonvulsant action of viloxazine in the rabbit.

The intravenous administration of the bicyclic antidepressant viloxazine, 0.5-2 mg/kg in rabbits, caused changes in the EEG profile with increased synchronous activity and shorter duration of the hippocampal afterdischarge following electrical stimulation. In animals exhibiting spontaneous epileptiform discharges, the injection of 1-2 mg/kg viloxazine was associated with disappearance of the paroxysmal EEG pattern that was substituted by a synchronous low frequency activity. This study also provided evidence of non-interactive effects of viloxazine (1-2 mg/kg i.v.) and alcohol (0.6 g/kg i.v.) on the EEG of normal rabbits.