Pawłowski L, Ruczyńska J, Wojtasik E
Pol J Pharmacol Pharm. 1979 Jul-Aug;31(4):261-9.
The effects of viloxazine on the flexor reflex of the hind limb of the spinal rat and the blood pressure in the pithed rat were studied. Viloxazine (1--16 mg/kg) stimulated the hind limb flexor reflex in the dose-dependent manner. This effect of viloxazine was inhibited by serotonin receptor blockers, cyproheptadine, danitracen and metergoline, and by serotonin uptake blocking agents imipramine and clomipramine. H22/54, an inhibitor of serotonin synthesis, was much less active in this respect. Desipramine, a noradrenaline uptake inhibitor, had no effect on the stimulatory action of viloxazine. Viloxazine (similarly as serotonin) elevated blood pressure in the pithed rat. This action of viloxazine was abolished by cyproheptadine but potentiated by pargyline, an inhibitor of MAO. It is suggested that viloxazine may facilitate the serotonergic transmission in the central nervous system.
研究了维洛沙嗪对脊髓大鼠后肢屈肌反射及去脑大鼠血压的影响。维洛沙嗪（1 - 16毫克/千克）以剂量依赖方式刺激后肢屈肌反射。维洛沙嗪的这一作用被5-羟色胺受体阻滞剂、赛庚啶、丹曲林和米替林以及5-羟色胺摄取阻滞剂丙咪嗪和氯米帕明抑制。5-羟色胺合成抑制剂H22/54在这方面活性低得多。去甲肾上腺素摄取抑制剂地昔帕明对维洛沙嗪的刺激作用无影响。维洛沙嗪（与5-羟色胺类似）使去脑大鼠血压升高。维洛沙嗪的这一作用被赛庚啶消除，但被单胺氧化酶抑制剂帕吉林增强。提示维洛沙嗪可能促进中枢神经系统中的5-羟色胺能传递。
