Subbiah M T, Deitemeyer D, Yunker R L
J Clin Invest. 1983 May;71(5):1509-13. doi: 10.1172/jci110906.
Cholesterol catabolism was stimulated in 6-wk-old White Carneau pigeons using a laboratory stock diet containing 1.3% cholestyramine resin. After 8 wk on this diet the animals were returned to control stock diet (no resin) for another 8-wk period. When subsequently challenged with a diet containing 0.5% cholesterol, cholestyramine-pretreated pigeons exhibited significantly lower serum cholesterol level when compared with controls and this "hyporesponder" behavior persisted throughout the study period. Furthermore, the aorta of cholestyramine-treated animals exhibited significantly (a) lower prevalence and severity of atherosclerosis and (b) lower cholesterol content. These studies demonstrate for the first time that enhancement of cholesterol catabolism in early life improves resistance to diet-induced atherosclerosis in later life in this avian model.
在6周龄的白卡诺鸽中，使用含有1.3%消胆胺树脂的实验室常规饲料刺激胆固醇分解代谢。在此饲料喂养8周后，将这些动物换回对照常规饲料（不含树脂），再持续喂养8周。随后，当用含有0.5%胆固醇的饲料进行挑战时，与对照组相比，经消胆胺预处理的鸽子血清胆固醇水平显著降低，并且这种“低反应者”行为在整个研究期间持续存在。此外，经消胆胺处理的动物的主动脉表现出：（a）动脉粥样硬化的发生率和严重程度显著降低，以及（b）胆固醇含量降低。这些研究首次证明，在这种禽类模型中，早期生活中胆固醇分解代谢的增强可提高后期对饮食诱导的动脉粥样硬化的抵抗力。
