Fujino M, Okada R, Arakawa K
Jpn Heart J. 1983 Jan;24(1):13-20. doi: 10.1536/ihj.24.13.
The effect of aging on histological changes of the conduction system was studied by serially sectioning 55 autopsied hearts weighing less than 300 Gm. None of the hearts showed evidence of cardiovascular disease nor were there any abnormalities in the clinical findings and ECG taken during the last 3 months of life. A reduction in the number of muscle cells and an increase in the number of collagen fibers were apparent in hearts taken from patients over 70 years of age. These findings were most evident in the S-A node and less so in A-V node, bundle of His, and left and right bundle branches. Deposition of amyloid substances was not observed in any portion of the conduction system.
通过对55例重量小于300克的尸检心脏进行连续切片，研究了衰老对传导系统组织学变化的影响。所有心脏均未显示心血管疾病迹象，在生命最后3个月的临床检查及心电图检查中也未发现任何异常。在70岁以上患者的心脏中，可见肌细胞数量减少，胶原纤维数量增加。这些发现以窦房结最为明显，房室结、希氏束以及左右束支则相对不那么明显。在传导系统的任何部位均未观察到淀粉样物质沉积。
