Nakayoshi N, Nunoi K, Ohnishi Y, Yamana Y, Minei M, Taniguchi Y
Jpn J Ophthalmol. 1983;27(1):255-60.
A prospective study was conducted in 36 diabetic patients to correlate the fasting blood sugar level (FBS) and the levels of hemoglobin A1 (HbA1) with the severity and progression of diabetic retinopathy. During an average follow-up of 12.6 +/- 2.9 months, the FBS and HbA1 levels were determined and progression of diabetic retinopathy assessed by fluorescein fundus angiography. The time-averaged HbA1 and FBS were correlated significantly. The HbA1 levels were significantly augmented in the order of good, fair and poor sugar control groups. The patients with progressive retinopathy had significantly higher FBS and HbA1 levels than the patients whose retinopathy remained unchanged. The correlation between the HbA1 level and the severity of retinopathy was not statistically significant. It was concluded that the combination of HbA1 and FBS levels will be useful for long-term control of diabetes and of progression of retinopathy.
对36例糖尿病患者进行了一项前瞻性研究，以关联空腹血糖水平（FBS）和糖化血红蛋白A1（HbA1）水平与糖尿病视网膜病变的严重程度和进展情况。在平均12.6±2.9个月的随访期间，测定FBS和HbA1水平，并通过荧光素眼底血管造影评估糖尿病视网膜病变的进展。时间平均HbA1和FBS显著相关。糖化血红蛋白水平在血糖控制良好、一般和较差的组中依次显著升高。视网膜病变进展的患者的FBS和HbA1水平显著高于视网膜病变未改变的患者。HbA1水平与视网膜病变严重程度之间的相关性无统计学意义。得出的结论是，HbA1和FBS水平的联合将有助于糖尿病的长期控制和视网膜病变的进展。
