Kopelson G
J Surg Oncol. 1983 Jun;23(2):99-103. doi: 10.1002/jso.2930230210.
Twenty-six patients with adenocarcinomas of the rectum, rectosigmoid, or sigmoid colon given adjuvant pre- or postoperative pelvic radiation therapy followed at least 5 years were retrospectively reviewed to evaluate late tumor control and complication rates. The overall 7-year survival rate was 80 +/- 8% with B2,3 patients faring better than C2,3 (94 +/- 6% versus 43 +/- 19%, p less than 0.005). Local pelvic tumor control was achieved in 23/26 patients (88%); patients with high-stage (C2,3) or poorly-differentiated adenocarcinomas had a higher postirradiation pelvic relapse rate (3/11) versus low stage, well or moderately-well differentiated tumors (0/15). A major complication (none fatal) occurred in 2 of 26 patients (8%) and was not correlated with either irradiation dose nor volume. Long-term follow-up is now available on patients who received adjuvant pelvic irradiation for rectal or sigmoid carcinomas and indicates a high pelvic tumor control rate. The 8% major complication rate may be decreased in the future by more sophisticated irradiation treatment planning.
对26例接受辅助性术前或术后盆腔放射治疗且随访至少5年的直肠、直肠乙状结肠或乙状结肠癌患者进行回顾性研究，以评估晚期肿瘤控制情况和并发症发生率。总体7年生存率为80±8%，B2、3期患者的预后优于C2、3期（分别为94±6%和43±19%，p<0.005）。26例患者中有23例（88%）实现了局部盆腔肿瘤控制；高分期（C2、3期）或低分化腺癌患者的放疗后盆腔复发率较高（3/11），而低分期、高分化或中分化肿瘤患者的复发率为0/15。26例患者中有2例（8%）发生了严重并发症（均无致命），且与照射剂量和照射体积均无相关性。目前已有对接受直肠或乙状结肠癌辅助盆腔照射患者的长期随访结果，显示盆腔肿瘤控制率较高。未来通过更精确的放射治疗计划，8%的严重并发症发生率可能会降低。
