Hardt T J, Ritschel W A
Methods Find Exp Clin Pharmacol. 1983;5(1):39-43.
The influence of various concentrations of coumarin (C) and 7-Hydroxycoumarin (7HC) upon in vitro macrophage phagocytosis of latex particles was investigated. A C dose of 20 micrograms/ml was indicated to have the greatest stimulating effect of all doses used with a percent effect of 25.6. A C dose of 80 micrograms/ml showed no apparent activity. C doses of 40, 10 and 1 microgram/ml had only a slight positive effect on phagocytosis compared to the control. 7HC concentrations of 80, 40, 20, 10 and 1 microgram/ml did not show any influence on the phagocytotic activity compared to the control. These preliminary data indicate a direct effect of C on macrophage function as has been suggested and refutes the hypothesis that 7HC is the pharmacologically active agent in reduction of high protein edemas.
研究了不同浓度的香豆素（C）和7-羟基香豆素（7HC）对体外巨噬细胞吞噬乳胶颗粒的影响。在所使用的所有剂量中，20微克/毫升的C剂量显示出最大的刺激作用，效应百分比为25.6。80微克/毫升的C剂量未显示出明显活性。与对照组相比，40、10和1微克/毫升的C剂量对吞噬作用仅有轻微的积极影响。与对照组相比，80、40、20、10和1微克/毫升的7HC浓度对吞噬活性均无任何影响。这些初步数据表明，正如所推测的那样，C对巨噬细胞功能有直接影响，并反驳了7HC是降低高蛋白水肿的药理活性剂这一假设。
