Svensson L
Lipids. 1983 Mar;18(3):171-8. doi: 10.1007/BF02534544.
The influence of dietary partially hydrogenated marine oils on distribution of phospholipid fatty acids in rat liver microsomes was studied with particular reference to the metabolism of linoleic acid. Five groups of weanling rats were fed diets containing 20% (w/w) peanut oil (PO), partially hydrogenated peanut oil (HPO), partially hydrogenated Norwegian capelin oil (HCO), partially hydrogenated herring oil (HHO), and rapeseed oil (RSO) for 10 weeks. The partially hydrogenated oils were supplemented with linoleic acid corresponding to 4.6 cal % in the diets. Accumulation of linoleic acid and reduced amount of total linoleic acid metabolites were observed in liver microsomal phospholipids from rats fed partially hydrogenated oils as compared to PO feeding. The most striking effects on the distribution of omega 6-polyunsaturated fatty acids was obtained after feeding HHO, a marine oil with a moderate content of trans fatty acids in comparison with HPO but rich in isomers of eicosenoic and docosenoic acids. Liver microsomal delta 6- as well as delta 5-desaturase activities as measured in vitro were reduced in rats kept on HHO as compared to PO dietary treatment. The results obtained suggest that the dietary influence of partially hydrogenated marine oils on the metabolism of linoleic acid might be better related to the intake of isomeric eicosenoic and docosenoic acids than to the total intake of trans fatty acids.
研究了膳食中部分氢化海洋油对大鼠肝脏微粒体中磷脂脂肪酸分布的影响，特别关注亚油酸的代谢。将五组断奶大鼠分别喂食含20%（w/w）花生油（PO）、部分氢化花生油（HPO）、部分氢化挪威毛鳞鱼油（HCO）、部分氢化鲱鱼油（HHO）和菜籽油（RSO）的饲料，持续10周。部分氢化油中添加了相当于饲料中4.6卡路里%的亚油酸。与喂食PO相比，喂食部分氢化油的大鼠肝脏微粒体磷脂中观察到亚油酸积累以及总亚油酸代谢物量减少。喂食HHO后，对ω-6多不饱和脂肪酸分布产生了最显著的影响，与HPO相比，HHO是一种反式脂肪酸含量适中但富含二十碳烯酸和二十二碳烯酸异构体的海洋油。与PO饮食处理相比，喂食HHO的大鼠肝脏微粒体δ-6-以及δ-5-去饱和酶的体外活性降低。所得结果表明，部分氢化海洋油对亚油酸代谢的膳食影响可能与异构二十碳烯酸和二十二碳烯酸摄入量的关系比与反式脂肪酸总摄入量的关系更密切。
