中枢给予血管活性肠肽可增加未麻醉家兔的纺锤波活动。

Centrally administered VIP increases spindle activity in unanaesthetized rabbits.

作者信息

Tartara A, Bo P, Savoldi F, Said S I

出版信息

Pharmacol Res Commun. 1983 Mar;15(3):307-16. doi: 10.1016/s0031-6989(83)80015-0.

Abstract

The action of VIP on structures responsible for cerebral electrical activity has been investigated in unanesthetized rabbits. VIP was given by slow infusion or bolus into the mesencephalic ventricle or the carotid artery, and topically applied on the motor or visual cortex. Both intracerebroventricular and intracarotid administration induced an increase of spindle activity of the cortex and an inhibition of the strychnine-transmitted spikes. These findings suggest a possible inhibitory role for VIP on certain CNS activity.

摘要

已在未麻醉的家兔中研究了血管活性肠肽（VIP）对负责大脑电活动结构的作用。通过缓慢输注或推注将VIP注入中脑室或颈动脉，并局部应用于运动或视觉皮层。脑室内和颈动脉内给药均诱导皮层纺锤体活动增加以及对士的宁传递的尖峰的抑制。这些发现提示VIP对某些中枢神经系统活动可能具有抑制作用。