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血管活性肠肽(VIP)可抑制前列腺素F2α诱导的兔子宫肌层活性。

Vasoactive intestinal polypeptide (VIP) inhibits prostaglandin-F2 alpha-induced activity of the rabbit myometrium.

作者信息

Ottesen B, Wagner G, Fahrenkrug J

出版信息

Prostaglandins. 1980 Mar;19(3):427-35. doi: 10.1016/0090-6980(80)90076-3.

DOI:10.1016/0090-6980(80)90076-3
PMID:7384549
Abstract

Seven female rabbits ahd myometrial autografts transplanted into ear-chambers. The electrical activity of the graft was recorded and mechanical activity observed. Vasoactive intestinal polypeptide (VIP) dose-dependently inhibited myometrial activity induced by prostaglandin-F2 alpha. This evidence and the occurrence of "VIPergic" nerve fibres, which seem to innervate the myometrial cells, suggest that VIP may play a physiological role in the local control of the myometrial activity.

摘要

七只雌性兔子的子宫肌层自体移植到耳腔中。记录移植物的电活动并观察其机械活动。血管活性肠肽(VIP)剂量依赖性地抑制前列腺素-F2α诱导的子宫肌层活动。这一证据以及似乎支配子宫肌层细胞的“VIP能”神经纤维的存在表明,VIP可能在子宫肌层活动的局部控制中发挥生理作用。

相似文献

1
Vasoactive intestinal polypeptide (VIP) inhibits prostaglandin-F2 alpha-induced activity of the rabbit myometrium.血管活性肠肽(VIP)可抑制前列腺素F2α诱导的兔子宫肌层活性。
Prostaglandins. 1980 Mar;19(3):427-35. doi: 10.1016/0090-6980(80)90076-3.
2
Effect of vasoactive intestinal polypeptide (VIP) upon myometrial blood flow in non-pregnant rabbit.血管活性肠肽(VIP)对未孕兔子宫肌层血流的影响。
Acta Physiol Scand. 1981 Jun;112(2):195-201. doi: 10.1111/j.1748-1716.1981.tb06804.x.
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Vasoactive intestinal polypeptide (VIP) inhibits oxytocin induced activity of the rabbit myometrium.
Acta Physiol Scand. 1979 Nov;107(3):285-87. doi: 10.1111/j.1748-1716.1979.tb06477.x.
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Vasoactive intestinal polypeptide (VIP): effect on rabbit uterine smooth muscle in vivo and in vitro.血管活性肠肽(VIP):对家兔子宫平滑肌的体内及体外作用
Acta Physiol Scand. 1981 Oct;113(2):193-9. doi: 10.1111/j.1748-1716.1981.tb06882.x.
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Effects of VIP in the female genital tract.血管活性肠肽在女性生殖道中的作用。
Endocrinol Jpn. 1980 Dec;27 Suppl 1:71-8. doi: 10.1507/endocrj1954.27.supplement_71.
6
[Effects of vasoactive intestinal polypeptide (VIP) on histamine or prostaglandin F-2alpha-induced bronchoconstriction (author's transl)].
Nihon Kyobu Shikkan Gakkai Zasshi. 1978 Dec;16(11):840-5.
7
Mechanism of action of vasoactive intestinal polypeptide on myometrial smooth muscle of rabbit and guinea-pig.血管活性肠肽对兔和豚鼠子宫肌层平滑肌的作用机制
J Physiol. 1981 Sep;318:41-55. doi: 10.1113/jphysiol.1981.sp013849.
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Increased myometrial blood flow evoked by vasoactive intestinal polypeptide in the non-pregnant goat.血管活性肠肽诱发非妊娠山羊子宫肌层血流增加。
J Physiol. 1981 Jan;310:471-80. doi: 10.1113/jphysiol.1981.sp013562.
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Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and oedema potentiator in rabbit skin.血管活性肠肽在兔皮肤中作为血管扩张剂和水肿增强剂比前列腺素E2更有效。
Br J Pharmacol. 1982 Nov;77(3):505-9. doi: 10.1111/j.1476-5381.1982.tb09324.x.
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Interaction of NPY and VIP in regulation of myometrial blood flow and mechanical activity.神经肽Y与血管活性肠肽在调节子宫肌层血流和机械活动中的相互作用。
Peptides. 1988 Mar-Apr;9(2):269-75. doi: 10.1016/0196-9781(88)90259-8.

引用本文的文献

1
Mechanism of action of vasoactive intestinal polypeptide on myometrial smooth muscle of rabbit and guinea-pig.血管活性肠肽对兔和豚鼠子宫肌层平滑肌的作用机制
J Physiol. 1981 Sep;318:41-55. doi: 10.1113/jphysiol.1981.sp013849.
2
Nervous release of vasoactive intestinal polypeptide from the feline uterus: pharmacological characteristics.猫子宫血管活性肠肽的神经释放:药理学特性。
J Physiol. 1982 Oct;331:451-60. doi: 10.1113/jphysiol.1982.sp014382.
3
Peptide-immunoreactive nerves in the mammalian female genital tract.哺乳动物雌性生殖道中的肽免疫反应性神经。
Histochem J. 1984 Dec;16(12):1297-310. doi: 10.1007/BF01003727.