Bakker C J, Vriend J
Phys Med Biol. 1983 Apr;28(4):331-40. doi: 10.1088/0031-9155/28/4/001.
Proton spin-lattice relaxation times were measured with pulsed NMR spectroscopy at 60 MHz for a range of tissues from healthy and tumour-bearing mice. T1 appeared to be significantly longer in the tumour than in any other tissue. Clearly distinct values of T1 were found for the vital and necrotic parts of the tumour. Non-involved tissues of tumour-bearing mice, viz. spleen, muscle, and salivary gland tissue, showed an increase in T1 relative to normal values. Irradiation of healthy mice with 6 MeV x-rays to a total-body dose of 15 Gy induced a shortening of T1 in the spleen. Similar experiments on tumour-bearing mice showed a decrease of T1 in the tumour, the spleen, the kidneys, and the liver. Attempts were made to interpret the results in terms of tissue hydration.
采用脉冲核磁共振波谱法在60兆赫频率下测量了健康小鼠和荷瘤小鼠一系列组织的质子自旋晶格弛豫时间。肿瘤组织中的T1似乎比其他任何组织都长得多。肿瘤的存活部分和坏死部分的T1值明显不同。荷瘤小鼠未受影响的组织，即脾脏、肌肉和唾液腺组织，其T1相对于正常值有所增加。用6兆电子伏特的X射线以15戈瑞的全身剂量照射健康小鼠，会导致脾脏中T1缩短。对荷瘤小鼠进行的类似实验表明，肿瘤、脾脏、肾脏和肝脏中的T1均降低。人们试图从组织水合作用的角度来解释这些结果。
