Richards M A, Webb J A, Jewell S E, Stansfeld A G, Lister T A, Wrigley P F
ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
Br J Cancer. 1988 Apr;57(4):408-11. doi: 10.1038/bjc.1988.92.
Low field strength (0.08 Tesla) magnetic resonance imaging (MRI) of the spleen with spin lattice relaxation time (T1) measurement was performed on a total of 79 healthy volunteers and 62 patients with lymphoma. Inhomogeneity was observed on the T1 images of the spleen from 25 volunteers. This was therefore considered a normal variant. The normal range of spleen T1 at 0.08 Tesla was established (362-420 msec). No influence of age on spleen T1 was detected. The range of T1 values observed in males and females was similar, although the mean spleen T1 for females was significantly longer than that for males. The sensitivity of T1 measurement for the detection of lymphoma in the spleen was poor, particularly for patients with Hodgkin's disease. In a minority of untreated patients, however, a spleen T1 value outside the normal range may indicate the presence of lymphoma in the spleen. A significant decrease in spleen T1 following treatment was observed in 9 patients who underwent serial scanning.
对79名健康志愿者和62名淋巴瘤患者进行了脾脏的低场强（0.08特斯拉）磁共振成像（MRI）检查，并测量了自旋晶格弛豫时间（T1）。在25名志愿者的脾脏T1图像上观察到不均匀性。因此，这被认为是一种正常变异。确定了0.08特斯拉时脾脏T1的正常范围（362 - 420毫秒）。未检测到年龄对脾脏T1有影响。尽管女性的脾脏T1平均值明显长于男性，但男性和女性观察到的T1值范围相似。T1测量对脾脏淋巴瘤检测的敏感性较差，尤其是对霍奇金病患者。然而，在少数未经治疗的患者中，脾脏T1值超出正常范围可能表明脾脏存在淋巴瘤。在9名接受系列扫描的患者中，观察到治疗后脾脏T1显著降低。
