Gemmell M A, Johnstone P D
Res Vet Sci. 1983 Mar;34(2):199-204.
Praziquantel was evaluated for its larvicidal activity against naturally or experimentally induced Taenia hydatigena infections in sheep. The major criterion used for assessing efficacy was an estimate of the dose rate required to free 90 per cent of the sheep from infection (ED90) together with a 95 per cent confidence interval. With both light and heavy infections of three-month-old T hydatigena in lambs up to 12 months old, many larvae were killed. The ED90 and 95 per cent confidence limits for six-month-old and aged organisms was estimated to be 13.1 (5.5 to 31.4) mg/kg and 6.1 (2.4 to 15.5) mg/kg, respectively. Equivalent data for the ED50 were 3.4 (1.4 to 8.3) mg/kg and 1.3 (0.3 to 5.4) mg/kg, respectively. It was established that one of the factors involved in the efficacy of praziquantel was associated with the age of the larvae at the time of treatment, the drug being markedly more effective against older than younger organisms.
对吡喹酮针对绵羊自然感染或实验诱导的泡状带绦虫感染的杀幼虫活性进行了评估。评估疗效的主要标准是估计使90%的绵羊免受感染所需的剂量率（ED90）以及95%的置信区间。在12月龄以下羔羊中，对3月龄泡状带绦虫的轻度和重度感染，许多幼虫被杀死。6月龄和老龄虫体的ED90及95%置信限估计分别为13.1（5.5至31.4）mg/kg和6.1（2.4至15.5）mg/kg。ED50的等效数据分别为3.4（1.4至8.3）mg/kg和1.3（0.3至5.4）mg/kg。已确定吡喹酮疗效涉及的因素之一与治疗时幼虫的年龄有关，该药物对老龄虫体的效果明显优于幼龄虫体。
