Thomas H, Gönnert R
Res Vet Sci. 1978 Jan;24(1):20-5.
Praziquantel is a new type of acylated isoquinoline-pyrazine. A single, low oral or subcutaneous dose of the compound is reliably effective against all tested juvenile and adult cestodes in cats, dogs and sheep. Praziquantel is the first cestodicide which is also effective on bile duct cestodes. In cats and dogs, 5 mg praziquantel per kg is completely effective on all stages of Taenia hydatigena, T pisiformis, T ovis, T taeniaeformis, Dipylidium caninum, Mesocestoides corti, Echinococcus multilocularis and E granulosus. Because of its very wide therapeutic index praziquantel is thus particularly suited for eradication programmes, eg, echinococcosis.
吡喹酮是一种新型的酰化异喹啉 - 吡嗪。单次低剂量口服或皮下注射该化合物，对猫、狗和绵羊体内所有测试的幼年和成年绦虫均有可靠疗效。吡喹酮是第一种对胆管绦虫也有效的杀绦虫剂。在猫和狗中，每千克体重5毫克吡喹酮对泡状带绦虫、豆状带绦虫、羊带绦虫、带状绦虫、犬复孔绦虫、中殖孔绦虫、多房棘球绦虫和细粒棘球绦虫的各个阶段均完全有效。由于其治疗指数非常宽，吡喹酮特别适合用于根除计划，如棘球蚴病。
