Nilsson T, Rudolphi O, Cedergren B
Scand J Haematol. 1983 Mar;30(3):201-6. doi: 10.1111/j.1600-0609.1983.tb01473.x.
Intensive plasmapheresis was performed on 7 alloimmunized pregnant women. About 60% of the plasma volume was removed each day, Monday to Friday, with pauses over the weekends. This treatment resulted in drops in immunoglobulin levels to about 1/3 of the pre-treatment concentrations, whereas the haemostatic parameters studied remained within normal limits. Thus, generally the treatment (as performed in this study) does not seem to induce changes that predispose for thrombotic or haemorrhagic complications. However, in one of the patients, antithrombin III became progressively depleted over the weeks of treatment. Therefore it is suggested that the patients be screened for their haemostatic profile prior to and after a few weeks of plasmapheresis treatment.
对7名同种免疫的孕妇进行了强化血浆置换。从周一到周五，每天去除约60%的血浆量，周末休息。这种治疗导致免疫球蛋白水平降至治疗前浓度的约1/3，而所研究的止血参数仍在正常范围内。因此，一般来说，（本研究中所进行的）这种治疗似乎不会引发易导致血栓形成或出血并发症的变化。然而，在其中一名患者中，抗凝血酶III在治疗的几周内逐渐减少。因此，建议在血浆置换治疗前及治疗几周后对患者进行止血情况筛查。
