Milman N, Bangsbøll S, Pedersen N S, Visfeldt J
Scand J Haematol. 1983 Apr;30(4):337-44. doi: 10.1111/j.1600-0609.1983.tb01502.x.
Serum ferritin and bone marrow haemosiderin iron was studied in 50 non-dialysis patients with chronic renal failure, and in 53 healthy subjects. S-ferritin was correlated to marrow iron both in patients with renal failure and in healthy subjects (P less than 0.001). Geometric-mean S-ferritin in patients with 0- (1+) marrow iron was 33 micrograms/l, 1+ marrow iron 166 micrograms/l, and 2+ marrow iron 519 micrograms/l. Healthy subjects with 0- (1+) marrow iron had a mean S-ferritin of 16 micrograms/l and those with 1+ marrow iron a value of 65 micrograms/l. S-ferritin levels were higher in patients than in healthy subjects at all marrow iron grades (P less than 0.001). Healthy subjects with S-ferritin less than 15 micrograms/l had absent or reduced marrow iron, while those with S-ferritin greater than 30 micrograms/l had normal marrow iron. Using a critical S-ferritin value of less than or equal to 20 micrograms/l, the diagnostic efficiency in terms of diagnosing absent or reduced marrow iron was 0.90 (PV pos = 0.85, Pv neg = 0.91). In patients with renal failure S-ferritin less than 60 micrograms/l indicated absent or reduced marrow iron, while values greater than 80 micrograms/l were associated with normal marrow iron. The diagnostic efficiency of S-ferritin using a critical value of less than or equal to 60 micrograms/l was 0.94 (PV pos = 0.93, PV neg = 0.97). S-ferritin is a useful indicator of marrow iron stores in patients with chronic renal failure.
对50例慢性肾衰竭非透析患者及53例健康受试者的血清铁蛋白和骨髓含铁血黄素铁进行了研究。在肾衰竭患者和健康受试者中，血清铁蛋白均与骨髓铁相关（P<0.001）。骨髓铁为0 - （1+）的患者血清铁蛋白几何均值为33微克/升，骨髓铁为1+的患者为166微克/升，骨髓铁为2+的患者为519微克/升。骨髓铁为0 - （1+）的健康受试者血清铁蛋白均值为16微克/升，骨髓铁为1+的健康受试者血清铁蛋白值为65微克/升。在所有骨髓铁分级中，患者的血清铁蛋白水平均高于健康受试者（P<0.001）。血清铁蛋白低于15微克/升的健康受试者骨髓铁缺乏或减少，而血清铁蛋白高于30微克/升的健康受试者骨髓铁正常。使用临界血清铁蛋白值小于或等于20微克/升，诊断骨髓铁缺乏或减少的诊断效率为0.90（阳性预测值=0.85，阴性预测值=0.91）。在肾衰竭患者中，血清铁蛋白低于60微克/升提示骨髓铁缺乏或减少，而高于80微克/升则与骨髓铁正常相关。使用临界值小于或等于60微克/升时，血清铁蛋白的诊断效率为0.94（阳性预测值=0.93，阴性预测值=0.97）。血清铁蛋白是慢性肾衰竭患者骨髓铁储存的有用指标。
