Birgegård G, Nilsson P, Wide L
Scand J Urol Nephrol. 1981;15(1):69-72. doi: 10.3109/00365598109181216.
Serum ferritin estimation was compared with bone marrow hemosiderin staining in the primary diagnosis of iron deficiency and overload in 19 patients on chronic hemodialysis. Serum ferritin estimation had a high predictive value: all 8 patients with marrow iron grade III had elevated S-ferritin values, and 3 out of 5 iron-deficient patients had subnormal values, the other 2 low-normal values. Serum iron and transferrin estimation was of very little value. Prophylactic treatment with 100 mg iron sulphate daily p.o. was inadequate for 13 of the 19 patients: 8 had iron overload. 5 had iron deficiency. Iron sulphate therapy was monitored by bone marrow hemosiderin and serum ferritin values and 15 patients could be followed up for one year. It was shown that serum ferritin estimations could be used to monitor the iron therapy.
对19例慢性血液透析患者进行缺铁和铁过载的初步诊断时，比较了血清铁蛋白测定与骨髓含铁血黄素染色的结果。血清铁蛋白测定具有较高的预测价值：所有8例骨髓铁分级为III级的患者血清铁蛋白值均升高，5例缺铁患者中有3例值低于正常，另外2例值略低于正常。血清铁和转铁蛋白测定价值甚微。19例患者中有13例每日口服100mg硫酸亚铁的预防性治疗不足：8例有铁过载，5例有缺铁。通过骨髓含铁血黄素和血清铁蛋白值监测硫酸亚铁治疗，15例患者可随访一年。结果表明，血清铁蛋白测定可用于监测铁治疗。
