Hedgecock E M, Sulston J E, Thomson J N
Science. 1983 Jun 17;220(4603):1277-9. doi: 10.1126/science.6857247.
Mutations in two nonessential genes specifically block the phagocytosis of cells programmed to die during development. With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths. Instead, these deaths appear to occur by cell suicide.
两个非必需基因的突变特异性地阻断了发育过程中被编程死亡的细胞的吞噬作用。除了少数例外，这些细胞仍然会死亡，这表明，在秀丽隐杆线虫中，大多数程序性死亡并不需要吞噬作用。相反，这些死亡似乎是通过细胞自杀发生的。
